de Grouchy syndrome is a rare congenital medical condition caused by an abnormality involving chromosome 18. It has two forms, classified as type 1 or type 2, depending on the nature of the genetic lesion.de Grouchy syndrome type 1 involves deletion of genes from the short arm of the chromosome (18p).de Grouchy syndrome type 2 occurs when the long arm of the chromosome is affected (18q). It manifests clinically as mental retardation, short stature, hypotonia, hearing impairment, and foot deformities. Tapered digits and wide mouth have been described. Approximately 80% of individuals affected by the syndrome are below the fifth centile in height. References^ http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601808^ Wilson, M. G.; Towner, J. W.; Forsman, I.; Sims, E.: Syndromes associated with deletion of the long arm of chromosome 18. Am. J. Med. Genet. 3: 155-174, 1979. PubMed ID : 474629

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